![]() ![]() Emotional stress, physical efforts, temperature change and sexual intercourse are common precipitating events of TGA. ![]() They remain alert and communicative without focal neurological signs, and their memory usually starts to recover after a few hours, returning to normal within a day. Despite the presence of profound amnesia, patients with TGA appear to have intact general cognition during the attack. Transient global amnesia (TGA) is an interesting syndrome of unknown etiology that is characterized by the abrupt onset of repetitive questioning. Ji of Seoul National University Bundang Hospital Institutional Review Board ( The authors received no specific funding for this work.Ĭompeting interests: The authors have declared that no competing interests exist. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: Data are available from the Seoul National University Bundang Hospital Institutional Review Board for researchers who meet the criteria for access to confidential data. Received: JAccepted: OctoPublished: October 14, 2016Ĭopyright: © 2016 Park et al. (2016) Transient Global Amnesia Deteriorates the Network Efficiency of the Theta Band. This effect might be related to the desynchronization between the anterior and posterior brain areas.Ĭitation: Park YH, Kim J-Y, Yi S, Lim J-S, Jang J-W, Im C-H, et al. Our results indicate that TGA deteriorates the network efficiency of the theta frequency band. The nCC of the theta band with a mean degree of 5.5 significantly decreased during the acute stage ( P < 0.05). During the acute stage, the lost edges for these networks were mostly found between the anterior (frontal and anterior temporal) and posterior (parieto-occipital and posterior temporal) brain regions, whereas newly developed edges were primarily found between the left and right frontotemporal regions. During the acute stage of TGA, the nCPL of the theta band networks with mean degrees of 8, 8.5, 9 and 9.5 significantly increased ( P < 0.05). For networks where the nCPL or nCC differed significantly between the two stages, we also evaluated changes in the connections of the brain networks. ![]() We investigated whether the normalized characteristic path length (nCPL) and normalized clustering coefficients (nCC) differed significantly between the acute and resolved stages of TGA at each frequency band using the Wilcoxon signed-rank test. Characteristic path lengths and clustering coefficients of functional networks constructed using phase-locking values were computed and normalized as a function of the degree in the delta, theta, alpha, beta 1, beta 2 and gamma frequency bands of the EEG. The EEG data were obtained twice, once during the acute stage ( 2 months after symptom onset) of TGA. ![]() Graph theoretical analysis was applied to resting-state EEG data collected from 21 patients with TGA. We tested the hypothesis that network efficiency, meaning the efficiency of information exchange over a network, is impaired during the acute stage of TGA. Acute perturbation of the hippocampus, one of the connector hubs in the brain, is a key step in the pathophysiological cascade of transient global amnesia (TGA). ![]()
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